Also indexed as: Zovirax Oral
Acyclovir is an antiviral drug used to treat shingles, genital herpes, and chickenpox.
Summary of
Interactions with Vitamins, Herbs, and Foods
In some cases, an herb or supplement may appear in more than one category, which may seem
contradictory. For clarification, read the full article for details about the summarized
interactions.
 May Be Beneficial: Supportive
interaction—Taking these supplements may support or otherwise help your medication
work better. |
Citrus root bark* Flavonoids* Geum japonicum* Rhus javanica* Syzygium aromaticum* Terminalia chebula* Tripterygium wilfordii* |
| Depletion or interference |
None known |
| Side effect reduction/prevention |
None known |
| Reduced drug absorption/bioavailability |
None known |
| Adverse interaction |
None known |
An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.
Interactions with Dietary Supplements
Flavonoids
The flavonoids quercetin, quercitrin, and
apigenin enhanced the antiviral activity of acyclovir in test tube studies.1
Controlled research is needed to determine whether taking quercetin or other flavonoid
supplements would increase the effectiveness of acyclovir in humans.
Interactions with Herbs
Citrus species
The alkaloid citrusinine-1 from the root bark of citrus plants has been shown to enhance the
antiviral activity of acyclovir.2 Further research is needed to determine whether
taking citrus root bark would increase the effectiveness of acyclovir in humans.
Tripterygium wilfordii
Test tube studies show that triptofordin C-2 increases the antiviral activity of acyclovir
against the herpes virus.3
Controlled human research is needed to determine whether taking tripterygium would increase
the effectiveness of acyclovir in humans.
Other Herbs
Animal studies have shown that other herbs, including Geum japonicum, Rhus javanica,
Syzygium aromaticum, and Terminalia chebula enhance the antiviral activity of
acyclovir.4 Controlled human studies are needed to determine whether taking these
herbs would increase the effectiveness of acyclovir in humans.
1. Mucsi I, Gyulai Z, Beladi I. Combined effects of flavonoids and acyclovir against herpesviruses in cell cultures. Acta Microbiol Hung 1992;39:137–47.
2. Yamamoto N, Furukawa H, Ito Y et al. Anti-herpesvirus activity of citrusinine-I, a new acridone alkaloid, and related compounds. Antiviral Res 1989;12:21–36.
3. Hayashi K, Hayashi T, Ujita K, Takaishi Y. Characterization of antiviral activity of a sesquiterpene, triptofordin C-2. J Antimicrob Chemother 1996;37:759–68.
4. Kurokawa M, Nagasaka K, Hirabayashi T et al. Efficacy of traditional herbal medicines in combination with acyclovir against herpes simplex virus type 1 infection in vitro and in vivo. Antiviral Res 1995;27:19–37.